Altered exercise performance and abnormal sympathetic response to exercise in patients with anorexia nervosa
1984
Nudel, Dov.B. | Gootman, Norman | Nussbaum, Michael P. | Shenker, I. Ronald
Extract: We evaluated the cardiovasculas and sympathetic response to exercise in patients with anorexia nervosa to determine whether their bradycardia results from a high level of physical fitness. Twenty adolescent patients with anorexia nervosa underwent maximal exercise tests, and the result were compared with those in 15 age-matched adolsecent girls. In the patients with anorexia maximal values were heart rate 174 bpm, systolic blood pressure 127, oxygen consumption 31/kg/min, and plasma norepinephrine concentration 1581 pg/ml. In the controls, corresponding values were signicantly higher heart rate 193 bpm, systolic blood pressure 163 mm Hg, oxygen consumption 39.3 ml/kg/min, and plasma noreppinephrine 2695. Anaerobic threshold occurred at the same percent of maximal work in patients and controls. Results of exercise ECGs in all controls were normal, but five patient with anorexia nervosa developed significant ST segment depression. Thus, in patients with anorexia nervosa there is abnormal working capacity and cardiovascular responses to exercise and abnormal sympathetic responses to the stimulus of exercise, and a myocardial abnormality manifested as ST segment depression during exercise in some. (Author)
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