An efficient wound healing hydrogel based on a hydroalcoholic extract of Moringa oleifera seeds
2022
Ali, Aaliya | Garg, Prakrati | Goyal, Rohit | Khan, Azhar | Negi, Poonam | Li, Xiangkai | Kulshrestha, Saurabh
The study aimed to assess the efficacy of formulated wound healing hydrogel based on a hydroalcoholic extract of Moringa oleifera seeds. In vitro antioxidant (using DPPH method) and antimicrobial activity (using agar well diffusion method) was studied. Male Swiss albino mice of weight 20- 30g were used. The hydrogel containing 5% and 10% of hydroalcoholic extract of Moringa oleifera seeds was used, whereas Povidone-iodine (5%) was used as standard. The wound healing efficacy of formulated hydrogel based on a hydroalcoholic extract of Moringa oleifera seeds was studied using excision and incision wound models. Assessments were taken on the 1ˢᵗ, 4ᵗʰ, 6ᵗʰ, 9ᵗʰ, 12ᵗʰ, 13ᵗʰ and 14ᵗʰ day in the excision model and on the 8ᵗʰ day in the incision model. Histopathological assessments were also done to support the study. Hydroalcoholic extract of Moringa oleifera seeds showed significant scavenging of free radicals showing antioxidant activity. Plant extract showed significant antimicrobial activity using the agar well diffusion method. The formulated hydrogels using the hydroalcoholic extract of Moringa oleifera seeds showed significant wound healing activity compared to both control (p<0.001) as well as standard treatment till 13ᵗʰ day (p<0.001) in excision wound. In the incision model, the topical application of formulated hydrogel significantly (p<0.001) increased the breaking strength. Furthermore, clarification of the positive results was shown by Histopathological investigation. The study presented here proved the hydrogels formulated using the hydroalcoholic extract of Moringa oleifera seeds could be used as an alternative therapy to manage wounds effectively.
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