Effect of probenecid on the pharmacokinetics of flunixin meglumine and phenylbutazone in healthy mares

Zertuche, J.M.L.; Brown, M.P.; Gronwall, R.; Merritt, K.

Effect of probenecid on the pharmacokinetics of flunixin meglumine and phenylbutazone in healthy mares

1992

Zertuche, J.M.L. | Brown, M.P. | Gronwall, R. | Merritt, K.

Pharmacokinetic values for flunixin meglumine (1 mg/kg of body weight) and phenylbutazone (4 mg(kg) dosages were determined after a single iv injection with and without concurrent intragastric administration of probenecid (50 mg/kg) in 6 healthy mares. Significant difference was not apparent in the pharmacokinetic values of flunixin meglumine with and without concurrent probenecid administration. Significant (P < 0.05) increase was evident in the 12-hour mean concentration of phenylbutazone (11.45 +/- 1.66 microgram/ml without probenecid; 14.56 +/- 1.20 microgram/ml with probenecid) along with significant (P < 0.05) reduction in its volume of distribution at steady state associated with concurrent probenecid administration (218.6 +/- 11.52 ml/kg without probenecid; 169.4 +/- 9.25 ml/kg with probenecid).

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