The effect of toxic components on metabolomic response of male SD rats exposed to fine particulate matter

Geng, Ningbo; Song, Xiaoyao; Cao, Rong; Luo, Yun; A, Mila; Cai, Zhengang; Yu, Kejie; Gao, Yuan; Ni, Yuwen; Zhang, Haijun; Chen, Jiping

The effect of toxic components on metabolomic response of male SD rats exposed to fine particulate matter

2021

PM₂.₅ pollution was associated with numerous adverse health effects. However, PM₂.₅ induced toxic effects and the relationships with toxic components remain largely unknown. To evaluate the metabolic toxicity of PM₂.₅ at environmentally relevant doses, investigate the seasonal variation of PM₂.₅ induced toxicity and the relationship with toxic components, a combination of general pathophysiological tests and metabolomics analysis was conducted in this study to explore the response of SD rats to PM₂.₅ exposure. The result of general toxicology analysis revealed unconspicuous toxicity of PM₂.₅ under environmental dose, but winter PM₂.₅ at high dose caused severe histopathological damage to lung. Metabolomic analysis highlighted significant metabolic disorder induced by PM₂.₅ even at environmentally relevant doses. Lipid metabolism and GSH metabolism were primarily influenced by PM₂.₅ exposure due to the high levels of heavy metals. In addition, high levels of organic compounds such as PAHs, PCBs and PCDD/Fs in winter PM₂.₅ bring multiple overlaps on the toxic pathways, resulting in larger pulmonary toxicity and metabolic toxicity in rats than summer.

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