Biotransformation of Jatrophone by Aspergillus niger ATCC 16404
2014
Pertino, Mariano | Schmeda-Hirschmann, Guillermo | Santos, Leonardo S. | Rodríguez, Jaime A. | Theoduloz, Cristina
Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC₅₀ values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compound 1 and 53.1 and 260 μM for 2, respectively. Microbial transformation of 1 into compound 2 strongly reduced the cytotoxicity and enhanced the selectivity against AGS cells.
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