A new trichothecene from Myrothecium roridum QDFE005, a symbiotic fungus isolated from Mactra chinensis
2013
Piao, Mei-Zi | Shen, Li | Wang, Feng-Wu
A new trichothecene, 12′-episatratoxin H (1), together with three known analogs: roridin A (2), 16-hydroxyroridin E (3), and roridin E (4), was isolated from the culture broth of the symbiotic fungus Myrothecium roridum QDFE005, which was isolated from Mactra chinensis . Their structures were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) techniques. Compound 1 exhibited significant cytotoxicity against the human tumor cell lines KB and HepG2 with IC ₅₀ values of 1.42 and 2.27 μM, respectively.
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