Chromium Treatment Has No Effect in Patients With Poorly Controlled, Insulin-Treated Type 2 Diabetes in an Obese Western Population: A randomized, double-blind, placebo-controlled trial
2006
Kleefstra, N. | Houweling, Sebastiaan T. | Jansman, Frank G.A. | Groenier, Klaas H. | Gans, Rijk O.B. | Meyboom-de Jong, Betty | Bakker, Stephan J.L. | Bilo, Henk J.G.
OBJECTIVE:--Chromium treatment has been reported to improve glycemic control and insulin sensitivity in specific populations of patients with type 2 diabetes. The aim of this study was to determine the effect of chromium treatment on glycemic control in a Western population of insulin-dependent patients with type 2 diabetes. RESEARCH DESIGN AND METHODS--In this 6-month double-blind study, patients with an HbA[subscript 1c] (A1C) >8% and insulin requirements of >50 units/day were randomly assigned to receive treatment with placebo or 500 or 1,000 [micro]g chromium daily in the form of chromium picolinate. The primary efficacy parameter was a change in A1C. Secondary end points were changes in lipid profile, BMI, blood pressure, and insulin requirements. RESULTS:--In this per-protocol analysis (n = 46), the decrease in A1C was approximately equal across the three groups (0.4%). All patients had a BMI >25 kg/m². No differences were found in the secondary end points. We found a weak relationship between an increasing serum chromium concentration and improvement of the lipid profile. CONCLUSIONS:--There is no evidence that high-dose chromium treatment is effective in obese Western patients with type 2 diabetes.
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