Synthesis of the Privileged 8-Arylmenthol Class by Radical Arylation of Isopulegol
2016
Crossley, Steven W. M. | Martinez, Ruben M. | Guevara-Zuluaga, Sebastián | Shenvi, Ryan A.
Hydrogen atom transfer (HAT) circumvents a disfavored Friedel–Crafts reaction in the derivatization of the inexpensive monoterpene isopulegol. A variety of readily prepared aryl and heteroaryl sulfonates undergo a formal hydroarylation to form 8-arylmenthols, privileged scaffolds for asymmetric synthesis, as typified by 8-phenylmenthol. High stereoselectivity is observed in related systems. This use of HAT significantly extends the chiral pool from the inexpensive monoterpene isopulegol.
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