Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists
2011
Buzard, Daniel | Han, Sangdon | Thoresen, Lars | Moody, Jeanne | López, Luis | Kawasaki, Andrew | Schrader, Thomas | Sage, Carleton | Gao, Yinghong | Edwards, Jeff | Barden, Jeremy | Thatte, Jayant | Fu, Lixia | Solomon, Michelle | Liu, Ling | Al-Shamma, Hussien | Gatlin, Joel | Lê, Minh | Xing, Charles | Espinola, Sheryll | Jones, Robert M.
S1P₁ receptor driven lymphopenia has proven utility in the treatment of an array of autoimmune disease states. As a part of our efforts to develop potent and selective S1P₁ receptor agonists, we have identified a novel chemical series of 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acid S1P₁ receptor agonists.
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