Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double‐blind randomized clinical trial
2021
Paknejad, Maryam Sadat | Eftekhari, Kambiz | Rahimi, Roja | Vigeh, Mohsen | Naghizadeh, Ayeh | Karimi, Mehrdad
This double‐blind study was designed to evaluate the efficacy of a syrup made from Myrtus communis L. fruit on children with gastroesophageal reflux disease. Children aged 1–7 years old, diagnosed with gastroesophageal reflux disease (GERD), were randomly allocated to either intervention group (omeprazole and “myrtle fruit syrup”) or control group (omeprazole and placebo syrup). GERD symptom questionnaire for young children (GSQ‐YC) was filled out for each patient at zeroth and eighth week, and also 4 weeks after cessation of intervention. No statistically significant difference between two groups in terms of GERD score was reported neither in 8th nor in 12th week assessments. During the 4 weeks of the drug‐free period, patients in myrtle group did not experience a large shift in GERD score, while patients in placebo syrup group experienced an increase of as much as 19.4. However, this difference was not statistically significant, although it could be significant clinically. For achieving more conclusive results, more studies are needed. The symptom “refusal to eat” in the intervention group was less than in placebo group after 8 weeks (p = .018) and at the end of the study (p = .042). So myrtle fruit syrup may be considered for children with low appetite.
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