Effects of aerobic exercise on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue
2019
Rodrigues, Aurora Corrêa | Leal, Tiago Ferreira | Costa, Alexandre Jayme Lopes Dantas | Silva, Franciany de Jesus | Soares, Leôncio Lopes | Brum, Patrícia Chakur | Hermsdorff, Helen Hermana Miranda | Peluzio, Maria do Carmo Gouveia | Prímola-Gomes, Thales Nicolau | Natali, Antônio José
Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β₁-AR⁻/⁻ mice adipose tissue.Four- to five-month-old male wild type (WT) and β₁-AR⁻/⁻ mice were divided into groups: WT control (WTc) and trained (WTt); and β₁-AR⁻/⁻ control (β₁-AR⁻/⁻c) and trained (β₁-AR⁻/⁻t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. After euthanasia, white epididymal (eWAT) and inguinal (iWAT) and brown (BAT) adipose tissues were dissected and used to determine: adiposity index; adipocyte histomorphometry; cytokine concentration; and gene expression. The content of fat, protein and water of the empty carcass was determined.MCAE reduced body weight, fat mass as well as iWAT and BAT adipocyte area in β₁-AR⁻/⁻ animals. Aerobic exercise also diminished the concentrations of pro-inflammatory (IL-12p70, TNF-α, IL-6) and anti-inflammatory (IL-10) cytokines in adipose tissue (iWAT, eWAT or BAT) of β₁-AR⁻/⁻ mice. However, MCAE had no effect on the expression lipolytic and thermogenic genes in β₁-AR⁻/⁻ mice adipose tissue.Alongside reductions in body weight, fat mass and adipocyte area eight weeks of MCAE improves the profile of inflammatory cytokines in β₁-AR⁻/⁻ mice adipose tissue, despite no change in Lipolytic and thermogenic gene expression.
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