Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis
2006
Li, Bo | Yu, John Paul J. | Brunzelle, Joseph S. | Moll, Gert N. | Van der Donk, Wilfred A. | Nair, Satish K.
Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
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