Visible-Light-Promoted Tandem Difluoroalkylation–Amidation: Access to Difluorooxindoles from Free Anilines
2017
Yu, Ling-Chao | Gu, Ji-Wei | Zhang, Shu | Zhang, Xingang
An efficient and synthetically convenient method for the synthesis of 3,3-difluoro-2-oxindole through a visible-light-induced photoredox difluoromethylation−amidation is described. The process can generate a broad range of difluorooxindoles using bromodifluoroacetate and broadly available free anilines. The wide range of substrate tolerance and mild reaction conditions make this transformation a highly valuable method in applications for drug discovery and development.
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