Determination of Boanmycin in Pharmaceutical Preparations by a Simple and Rapid Ion-pair LC Method
2009
Liu, Yu | Yoo, Sun Dong | Fang, Liang | Jin, Xin | Li, Li | Ren, YanJun | Yao, ChongShun | Li, Tiefu
An ion-pair HPLC method with UV detection is described for the determination of boanmycin in freeze-dried pharmaceutical preparations. Chromatographic separation was achieved on a 5 μm Agilent Eclipse XDB-C₁₈ column (150 x 4.6 mm). The mobile phase contained methanol, acetonitrile, 055 M sodium hexanesulfonate and 0.08 M acetic acid in water. UV detection was at 291 nm. The assay was validated over a linear concentration range from 0.05 to 120 μg mL⁻¹. The method was applied to determine the content of BAM in freeze-dried powders.
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