Easy access to triazolinedione-endcapped peptides for chemical ligation
2017
WilkeThese authors contributed equally to this work., P. | Kunde, T. | Chattopadhyay, S. | ten Brummelhuis, N. | Du Prez, F. E. | Börner, H. G.
An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly(ε-caprolactone) of different molecular weights. The ligation proved to be orthogonal to a variety of functional groups present in natural amino acids.
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