Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds

Xu, Hui; Fan, Guang-Peng; Liu, Zi; Wang, Guan-Wu

Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds

2018

Xu, Hui | Fan, Guang-Peng | Liu, Zi | Wang, Guan-Wu

A regioselective, solvent-free and catalyst-free synthesis of isoxazoles has been successfully developed under ball milling conditions. Milling the mixtures of N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds in a ball mill at a frequency of 14.6 Hz for 20–60 min afforded isoxazoles in up to 86% yields. A possible reaction mechanism leading to the formation of the observed isoxazoles is proposed.

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Ключевые слова АГРОВОК

carbonyl compounds chemical reactions chemical structure milling organochlorine compounds

Библиографическая информация

Опубликовано в

Tetrahedron

Том 74 Выпуск 45 Нумерация страниц 6607 - 6611 ISSN 0040-4020

Издатель

Elsevier Ltd

Другие темы

Mechanochemistry; Reaction mechanisms; Solvent-free; Enamino carbonyl compounds; N-hydroxybenzimidoyl chlorides; Catalyst-free; Isoxazoles; Mechanochemistry; Regioselectivity

Язык

Английский

Тип

Journal Article; Text

В АГРИСе с: 2024-02-28

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

Откройте коллекцию этого поставщика данных в AGRIS

Ссылки

DOI DOI https://dx.doi.org/10.1016/j.tet.2018.09.044

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