Lipase-catalyzed synthesis of capsaicin analogs by amidation of vanillylamine with fatty acid derivatives
1998
Kobata, K. | Kawamura, M. | Toyoshima, M. | Tamura, Y. | Ogawa, S. | Watanabe, T.
Various lipases catalyzed the synthesis of capsaicin analogs by amidation of vanillylamine with fatty acid derivatives in a two-phase system. When methyl myristate was employed as an acyl donor, moderate yields, 40-59%, of capsaicin analog (3) were obtained using Novozym 435, Lipase AK or Lipase PS. Several capsaicin analogs having 4-18 carboxyl carbons were also synthesized from the corresponding fatty acid or its methyl or ethyl ester in 2-44% yields.
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