Effect of dietary Acrocomia aculeata kernel oil rich in medium chain fatty acids on type 2 diabetic rats
Nunes, Ângela Alves | Buccini, Danieli Fernanda | dos Santos Jaques, Jeandre Augusto | Portugal, Luciane Candeloro | Guimarães, Rita Cássia Avellaneda | Favaro, Simone Palma | Caldas, Ruy de Araújo | Carvalho, Cristiano Marcelo Espinola
This study evaluated the effects of dietaries formulated with kernel oil of Acrocomia aculeata (AKO), rich in medium chain fatty acids (MCFA), as partial substitute of carbohydrate calories upon blood glucose, lipid profile, insulin secretion and insulin sensitivity in diabetic rats. Overall, the dietary with any AKO dose reduced hyperglycemia, ameliorated insulin secretion, lowered insulin resistance by model HOMA-IR and HOMA-β and augmented pancreatic beta cells functionality, restored the number of pancreatic β-cell in the diabetic rats and increased it in the non-diabetic rats. In addition, AKO fed rats showed reducing triglycerides, lower density lipoprotein-cholesterol and increasing high density lipoprotein-cholesterol levels, and improved hepatic function markers. Those findings suggest AKO was effective to ameliorate the health of diabetic rats.
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