Vitamin B2 status in athletes and the influence of riboflavin administration on neuromuscular irritability
1976
Haralambie, Georg
Extract: In order to obtain information on the vitamin B2 status in athletes in training, the following aspects were investigated: in one group of athletes, riboflavinuria at rest, during the autumn and winter months; in the second group, the activity of the nicotinamide adenine denucleotide phosphate dependent red blood cell glutathione reductase and its activation by added flavin adenine dinucleotide. In 8 athletes, activation coefficients higher than 1.25 were found, indicating a biochemical deficiency of riboflavin. Erythrocyte transketolase was activated by more than 25% with added thiamine pyrophosphate in 12 cases. In muscle samples of 10 healthy patients, glutathione reductase was activated by more than 25% in 5 cases. Administration of 10 mg of riboflavin per os resulted in moderate lowering of neuromuscular irritability particularly for 0.1 msec rectangular stimuli.
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