Hyperglycemia associated with the therapeutic use of L-asparaginase: Possible role of insulin receptors
1978
Carpentieri, Ugo | Balch, Michael T.
Extract: A study of four children, two with acute lymphocytic leukemia and two with non-Hodgkin lymphoma, treated for three days with 1-asparaginase, suggests that insulin receptors may be involved in the hyperglycemia associated with the use of L-asparaginase. Comparison of insulin receptors of circulating monocytes revealed a marked decrease in their number after treatment. This might also explain the lack of response to insulin treatment in one of the patients with symptomatic hyperglycemia.
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