Exposure Assessment of Prepubertal Children to Steroid Endocrine Disruptors. 2. Determination of Steroid Hormones in Milk, Egg, and Meat Samples
Courant, F. | Antignac, J.P. | Laille, J. | Monteau, F. | André, F. | Le Bizec, B.
In the present study, the occurrence of the main sex steroid hormones in milk, egg, and meat was evaluated on the basis of a highly specific gas chromatography-tandem mass spectrometry measurement method. Globally, the results indicated that targeted estrogens and androgens occurred at similar levels (concentration levels in the 10-100 ng kg-1 range) in the analyzed muscle and milk samples. The same compounds occurred at about 10-fold higher concentrations (i.e., in the 100-1000 ng kg-1 range) in eggs and kidney samples. More precisely, egg and milk appeared as a non-negligible sources of estradiol (i.e., 2.2 0.8 and 3.1 2.0 ng day-1, respectively), whereas testosterone exposure is caused by ingestion of meat and/or egg (i.e., 12.2 48.2 and 5.2 2.3 ng day-1, respectively). The provided exposure data will be further exploited in the scope of a risk assessment study regarding endocrine disruption associated with these molecules.
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