Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation
2011
King, Katherine | Chapman, Dave | Argilaguet, Jordi M. | Fishbourne, Emma | Hutet, Evelyne | Cariolet, Roland | Hutchings, Geoffrey | Oura, Christopher A.L. | Netherton, Christopher L. | Moffat, Katy | Taylor, Geraldine | Le Potier, Marie-Frederique | Dixon, Linda K. | Takamatsu, Haru-H.
African swine fever (ASF) is an acute haemorrhagic disease of domestic pigs for which there is currently no vaccine. We showed that experimental immunisation of pigs with the non-virulent OURT88/3 genotype I isolate from Portugal followed by the closely related virulent OURT88/1 genotype I isolate could confer protection against challenge with virulent isolates from Africa including the genotype I Benin 97/1 isolate and genotype X Uganda 1965 isolate. This immunisation strategy protected most pigs challenged with either Benin or Uganda from both disease and viraemia. Cross-protection was correlated with the ability of different ASFV isolates to stimulate immune lymphocytes from the OURT88/3 and OURT88/1 immunised pigs.
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