The effect of carbohydrate and fat variation in euenergetic diets on postabsorptive free fatty acid release
2002
Bisschop, P.H. | Ackermans, M.T. | Endert, E. | Ruiter, A.F.C. | Meijer, A.J. | Kuipers, F. | Sauerwein, H.P. | Romijn, J.A.
Diet composition and energy content modulate free fatty acid (FFA) release. The aim of this study was to evaluate the dose-response effects of euenergetic variations in dietary carbohydrate and fat content on postabsorptive FFA release. The rate of appearance (R(a) of palmitate was measured by infusion of [2,2-2H2]palmitate after an overnight fast in six healthy men on three separate occasions, i.e. after 7 d on euenergetic control, high-carbohydrate and high-fat diets. The protein content and composition was identical for each diet. Postabsorptive plasma fatty acid concentrations were not different between the high-carbohydrate and control diets (0.36 (SE 0.07) v. 0.43 (SE 0.04) mmol/l), but were increased after the high-fat diet (0.75 (SE 0.09) mmol/l, (P<0.01 compared with the other diets). R(a) palmitate was not different between the high-carbohydrate and control diets (1.36 (SE 0.20) v. 1.47 (SE 0.15) micromol/kg per min). However, R(a) palmitate was increased to 2.36 (SE 0.26) micromol/kg per min after the high-fat diet (P<0.01 compared with the other diets). The fatty acid flux and whole-body fat oxidation were not affected by the high-carbohydrate diet compared with the control diet, but were increased by 67 and 47% respectively, on the high-fat diet (P<0.01 compared with the other diets). A euenergetic high-fat diet results in increased postabsorptive FFA release and fat oxidation, whereas a euenergetic high-carbohydrate diet does not affect these variables of fat metabolism.
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