Homology of the Lpm system of allotypes in the American mink and the Gp system of allotypes in the domestic pig
Ermolaev, V.I. | Mirtskhulava, E.G. | Savina, M.A. | Gorelov, I.G. | Matichashvili, R.S. | Baranov, O.K.
The article presents the results of a search in pigs for allotypes of a protein homologous to the Lpm-macroglobulin (alpha 1M) of the mink and a study of the organization of the corresponding immunogenetic system. For this purpose antisera detecting five allotypes of the alpha-macroglobulins were selected from the bank of reagents previously produced for porcine serum protein allotypes. It was established that the alpha M1 allotype is a marker of a protein homologous to the mink alpha 2M and the human alpha 2M. The remaining allotypes (alpha M2-alpha M5) mark the second isotypic variant of porcine alpha-macroglobulins, homologous to the mink Lpm (alpha 1M). The materials of the international comparative test showed that the alpha M1 marker is a new allotype, while alpha M2-alpha M5 correspond to four allotypes of the Gp system (globulin of pig) described previously. On the basis of these immunochemical data it was concluded that the Lpm system of the American mink and the GP system of the pig are homologous. Since the investigated allotypes belong to alpha-macroglobulins, it is suggested that the locus controlling them be called the AM locus. It is advisable to give the same notation to the homologous locus of the mink, instead of the previously used Lpm, The genetic control of the five allotypes was studied and the structure of the porcine AM locus was analyzed in detail. The organization of this locus in the pig is compared with the homologous locus of the mink.
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