Bioavailability, pharmacokinetics, and plasma concentration of tetracycline hydrochloride fed to swine

Kniffen, T.S.; Bane, D.P.; Hall, W.F.; Koritz, G.D.; Bevill, R.F.

Bioavailability, pharmacokinetics, and plasma concentration of tetracycline hydrochloride fed to swine

1989

Kniffen, T.S. | Bane, D.P. | Hall, W.F. | Koritz, G.D. | Bevill, R.F.

A 2 X 2 crossover design trial was conducted in gilts to determine the bioavailability and pharmacokinectics of tetracycline hydrochloride. The bioavailability of tretracycline hydrochloride administered orally to fasted gilts was approximately 23%. After intravascular administration, the disposition kinetics of tetracycline in plasma were best described by a triexponential equation. The drug had a rapid distribution phase followed by a relatively slow elimination phase, with half-life of 16 hours. Its large volume of distribution (4.5 +/- 1.06 L/kg) suggested that tetracycline is distributed widely in swine tissues. Total body clearance was 0.185 +/- 0.24 L/kg/h. Other pharamacokinectic variables were estimated. In a second trial, 3 gilts were fed a ration containing 0.55 g of tetracycline hydrochloride/kg of feed. Resulting plasma concentration of tetracycline was determined at selected times during 96 hours after exposure to the medicated feed. Plasma drug concentration peaked (0.6 microgram/ml) at 72 hours after access to the medicated feed.

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