Efficacy of ginkgolic acids against Cryptosporidium andersoni in cell culture
2011
Wu, Liang | Jiang, Xu-gan | Shen, Yu-juan | Lu, Zhao-xi | Tu, Guo-hua | Fu, Xing-li | Chen, Sheng-xia | Cao, Jian-ping
Cryptosporidium is a worldwide waterborne parasite and the treatment is a severe problem in immunocompromised patients. In this study, we used the in vitro culture system to evaluate the anti-Cryptosporidium activity of ginkgolic acids (GAs), nitazoxanide (NTZ), garlicin (GAR), and artemether (ART). The growth of Cryptosporidium andersoni in HCT-8 cells was determined by real-time PCR assay. When exposed to 5.00 μg/ml GAs or 10.00 μg/ml NTZ for 48 h, the number of C. andersoni in cultures was on a very low lever, but the number of parasites did not significantly decrease when exposed to GAR and ART. Our results indicate that GAs could be a potential drug for the treatment of cryptosporidiosis.
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