A, D-seco-Limonoids from the Stems of Clausena emarginata
2014
Xia, Hong-Min | Li, Chuang-Jun | Yang, Jing-Zhi | Ma, Jie | Chen, Xiao-Guang | Zhang, Dan | Li, Li | Zhang, Dong-Ming
Twelve new A,D-seco-limonoids, clauemargines A–L (1–12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8–10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC₅₀ values < 10 μM).
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