The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair
Jimenez, G. | Yucel, J. | Rowley, R. | Subramani, S.
A number of important molecular checkpoints are believed to control the orderly progression of cell cycle events. We have found that the radiation-sensitive Schizo-saccharomyces pombe mutant rad3-136 is deficient in two molecular checkpoint functions. Unlike wild-type cells, the mutant cells are unable to arrest in the G2 phase of the cell cycle after DNA damage by gamma-irradiation and are also incapable of maintaining the dependence of mitosis upon the completion of DNA synthesis. An S. pombe genomic clone that complements the UV sensitivity of the rad3-136 mutant completely restores the missing checkpoint functions. The rad3 gene is also likely to play a role in DNA repair.
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