An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis
2019
Liu, Jin-Yu | Yang, Xie-Chao | Liu, Zhen | Luo, Yong-Chun | Lu, Hong | Gu, Yu-Cheng | Fang, Ran | Xu, Peng-Fei
A variety of axially chiral biaryldiols were synthesized in good yields with excellent atropo-enantioselectivities through construction of axially chiral indoles catalyzed by asymmetric hydrogen-bond donors. In addition, the new axially chiral compounds were proved to be efficient and practical catalysts for asymmetric catalysis. The strategy not only provides a novel method to synthesize axially chiral compounds but also extends the scope of chiral catalysts.
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