Biomass-derived porous carbon with high drug adsorption capacity undergoes enzymatic and chemical degradation
2022
Xu, Guohao | Zhang, Wenjuan | Du, Juan | Yuan, Xiaoling | Zhang, Wenxiang | Yan, Wenfu | Liu, Gang
Degradability is a key safety issue when choosing materials for biomedical applications and environmental protection. This factor greatly limits the application of porous carbon in these areas due to the inert and stable nature of carbon network. In this work, this conflict could be well-resolved by rational designing a mesoporous carbon (MC) with biomass as a carbon source. The retained oxygen-containing species simultaneously increase drug adsorption capacity and the degradability of MC. The maximum adsorption quantity for doxorubicin over MC can reach 395.3 mg/g, about 3-fold over carbon nanotubes. The detailed analysis reveals that the degradation of MC occurs via a radical mediated oxidation process. The high electron density feature of MC facilitates the electrophilic addition reaction in the presence of HO. During this process, the carbon network is gradually degraded into fragments, carbon nanodots and ultimately to CO₂. This work opens up a new way to fabricate degradable porous materials and provides a promising material for the practical application in biomedical and environmental field.
Показать больше [+] Меньше [-]Ключевые слова АГРОВОК
Библиографическая информация
Эту запись предоставил National Agricultural Library