Phenolics from Leontopodium leontopodioides inhibiting nitric oxide production
2012
Li, Xin | Luo, Jian-Guang | Wang, Xiao-Bing | Luo, Jun | Wang, Jun-Song | Kong, Ling-Yi
Two new compounds, a neolignan (1), and a benzofuran derivative (2), along with 6 known compounds (3–8), were isolated from the aerial parts of Leontopodium leontopodioides. The structures of the new compounds were elucidated as (7R,8S)-3,5′-dimethoxy-4′,7-epoxy-8,3′-neolignane-5,9,9′-triol (1) and (2R)-12-hydoxy-4-methoxy-tremeton (2) on the basis of their spectroscopic data, respectively. All of the isolates were evaluated for their effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages and compounds 1 and 8 exhibited inhibitory activity with IC₅₀ values of 35.80 and 24.41μM, respectively.
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