Dynamic diastereomeric salt resolution of narwedine and its transformation to (-)-galanthamine
1998
Chaplin, D.A. | Johnson, N.B. | Paul, J.M. | Potter, G.A.
Racemic narwedine may be resolved by means of a dynamic diastereomeric salt formation using di-p-toluoyl-D- tartaric acid. Both the 1:1 and 2:1 salts are formed in excellent yields and diastereomeric excesses. These salts are reduced in a highly diastereoselective and chemoselective manner to give (-)-galanthamine.
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