Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7′-Oxodihydroguaiaretic Acid
2008
YAMAUCHI, Satoshi | Masuda, Toshiya | SUGAHARA, Takuya | KAWAGUCHI, Yuya | OHUCHI, Maya | SOMEYA, Tatsushi | AKIYAMA, Jun | TOMINAGA, Shiori | YAMAWAKI, Manami | KISHIDA, Taro | AKIYAMA, Koichi | MARUYAMA, Masafumi
The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7′-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.
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