Asymmetric synthesis of 2-chloroaziridines via a diastereoselective nucleophilic dichloromethylation and N-alkylation in one pot
2018
Zhang, Yuxuan | Tian, Hongchang | Luo, Zhengshan | Liu, Xiongtong | Zhao, Yinjiao | Chen, Wen | Zhang, Hongbin
A diastereoselective nucleophilic dichloromethylation between the N-tert-butanesulfinyl imines and dichloromethyllithium was developed. A series of 2-chloroaziridines with excellent yields and dr values were obtained via this nucleophilic addition and N-alkylation in one pot. On the basis of X-ray crystallography experiment, the predicting model for this diastereoselective transformation was provided.
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