Proteolytic stability of cyclic α-hydrazino acid containing peptides: a qualitative study
2016
Duttagupta, Indranil | Bhadra, Jhuma | Das, Sanjib Kr | Sinha, Surajit
Synthesis of cyclic α-hydrazino acid containing tripeptides Phe-X-Val and evaluation their proteolytic stability against digestive enzymes has been reported for the first time. Tripeptides were treated with the digestive juice of mice and incubated in buffer at 37°C for 45min and was found to be stable when X=5,6,7-membered hydrazino acids with δ-NH/NHCbz whereas X=proline was digested. Digestion process was monitored by LC–MS analysis.
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