Assessing the welfare of genetically modified mice
2002
Francis, R.J.
In the United Kingdom, research that uses genetically modified animals requires a project license, granted under The Animals (Scientific Procedures) Act 1986 (ASPA). All project license applicants are required to make a cost/benefit analysis of the work that is to be carried out on the animals, in addition to predicting the adverse effects on the animals that are likely to result from the procedures. During the creation of genetically modified animals, the uncertainty of the effect of the DNA modification can lead to unexpected adverse effects that could have major welfare consequences for the animals involved. The effect can be negligible or, in other cases, extreme. Extreme effects can include: embryonic lethality, deformity, sterility, major organ malfunction, and epileptic seizure. The present study addresses how the welfare of genetically modified mice can be assessed.
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