Effect of Corynebacterium pseudotuberculosis phospholipase D on viability and chemotactic responses of ovine neturophils

Yozwiak, M.L.; Songer, J.G.

Effect of Corynebacterium pseudotuberculosis phospholipase D on viability and chemotactic responses of ovine neturophils

1993

Yozwiak, M.L. | Songer, J.G.

Corynebacterium pseudotuberculosis phospholipase D (PLD) significantly affected viability of ovine neutrophils after 24 hours' exposure, This effect was more marked in cells that ingested PLD emulsified in oil. Treatment of neutrophils with PLD significantly (P < 0.05) reduced the ability of these cells to migrate toward activated sheep serum. The PLD was not chemotactic, but it activated normal sheep serum, producing factors that were chemotactic for neutrophils.

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