Histone modifications: from genome-wide maps to functional insights
2005
Leeuwen, Fred van | van Steensel, Bas
A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.
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