Deoxynivalenol damages the intestinal barrier and biota of the broiler chickens
Wan, Shuangxiu | Sun, Na | Li, Hongquan | Khan, Ajab | Zheng, Xiaozhong | Sun, Yaogui | Fan, Ruiwen
BACKGROUND: In the livestock feed industry, feed and feed raw materials are extremely susceptible to mycotoxin contamination. Deoxynivalenol (DON) is one of the main risk factors for mycotoxin contamination in broiler feed and feedstuff, however, there is still little knowledge about this. Hence, the purpose of this study was to explore the toxicity effect of DON on the intestinal barrier and the microecological balance of the biota in broiler chickens. RESULTS: In our present study, we compared the pathological scores of the small intestines of broilers on the 5ᵗʰ, 7ᵗʰ, and 10ᵗʰ day, and chose the 7ᵗʰ day to analyze the small intestine histomorphology, tight junctions, and cecal biota of the broilers. The results showed the damage to the small intestine worsened over time, the small intestinal villi of broilers were breakage, the tight junctions of the small intestine were destroyed, the cecal biota was unbalanced, and the growth performance of broilers was reduced on the 7ᵗʰ day. CONCLUSIONS: DON could damage the functional and structural completeness of the intestinal tract, disorder the Intestinal biota, and finally lead to declined broiler performance. Our study provided a basis for the prevention and treatment of DON in broiler production.
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