Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes
2016
Pérez-Galán, Patricia | Waldmann, H. (Herbert) | Kumar, Kamal
A gold(I) catalyzed cycloisomerization of indolyl-1,6-enynes via 5-exo-dig cyclization is reported. The reaction passes through an intermediate whose fate can be steered to yield different indole polycyclic scaffolds through various intra- and inter-molecular cyclization reactions. One of the key transformations of indolyl-1,6-enynes was a formal [2+2+2] cycloaddition reaction with various aldehydes to afford natural product-like tetracyclic indoles.
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