Changes in antioxidant status and biochemical parameters after orally cadmium administration in females rats
2009
Chater, S. | Douki, T. | Favier, A. | Sakly, M. | Abdelmelek, H.
The research was conducted to investigate the toxic effects of cadmium chloride (CdCl <sub>2</sub>), administered during gestation period on female Wistar rats. Pregnant rats received CdCl <sub>2</sub> (20 mg/l, orally) from Day 6 to Day 19 of pregnancy. Results showed that Cd treatment induced a decrease in body weight gain. The relative liver weight increased significantly, with a marked decrease of glycogen and total lipids content. The administration of Cd induced hepatotoxicity as indicated by elevations in plasma alanine aminotransferase (ALT), aspartate aminotransferase and lactate dehydrogenase (LDH) activities (<i>p</i> < 0.05). Treatment with CdCl <sub>2</sub> caused a significant (<i>p</i> < 0.05) increase in glucose. A significant increase was observed in the level of MDA and 8-oxodGuo tissues in the cadmium-exposed group compared to the control group (<i>p</i> < 0.05). Results showed that cadmium given to dams led to an oxidative stress and DNA damage in tissues of pregnant rats.
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