The stability of all-trans retinol and reactivity towards transition metals
1991
Manan, F. | Guevara, L.V. | Ryley, J.
The stability, of all-trans retinol in solution and in a simple models system was studied by high performance liquid chromatography. Approximately 50% all-trans retinol was decomposed in chlorinated solvents exposed to sunlight (20 min) and in methanol under ultra violet light (30 min) at laboratory temperature. All the degradation products (9-cis, 9, 13 dis-cis, 11-cis, 11, 13 di-cis) were higher in chlorinated solvents than non-chlorinated solvents and 9-cis and 13-cis retinol were the major isomers in all the solvents during sunlight included photolysis. Assay of all-trans retinol dispersed on a microcrystalline cellulose model system showed that the preparation technique affected the % recovery and the precision of the method. About 93% of the all-trans retinol was recovered from well-homogenised model systems (MS1, MS2) and the recovery was not affected by the level of addition. Mineral fortification had a significant effect on the retinol stability and the half-life dropped to approximately, 1/3 and 1/4 of the unsupplemented value due to iron and copper supplementation, respectively. The loss of all-trans retinol followed first order kinetics.
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