Close association of intestinal autofluorescence with the formation of severe oxidative damage in intestine of nematodes chronically exposed to Al₂O₃-nanoparticle
2011
Yu, Shunhui | Rui, Qi | Cai, Ting | Wu, Qiuli | Li, Yinxia | Wang, Dayong
In nematodes, acute exposure (24-h) to 8.1–30.6mg/L Al₂O₃-nanoparticles (NPs) or Al₂O₃ did not influence intestinal autofluorescence, whereas chronic exposure (10-d) to Al₂O₃-NPs at concentrations of 8.1–30.6mg/L or Al₂O₃ at concentrations of 23.1–30.6mg/L induced significant increases of intestinal lipofuscin accumulation, and formation of severe stress response and oxidative damage in intestines. Moreover, significant differences of intestinal autofluorescence, stress response and oxidative damage in intestines of Al₂O₃-NPs exposed nematodes from those in Al₂O₃ exposed nematodes were detected at examined concentrations. Oxidative damage in intestine was significantly correlated with intestinal autofluorescence in exposed nematodes, and oxidative damage in intestine was more closely associated with intestinal autofluorescence in nematodes exposed to Al₂O₃-NPs than exposed to Al₂O₃. Thus, chronic exposure to Al₂O₃-NPs may cause adverse effects on intestinal lipofuscin accumulation by inducing the formation of more severe oxidative stress in intestines than exposure to Al₂O₃ in nematodes.
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