Current strategies for subunit and genetic viral veterinary vaccine development
Brun, Alejandro | Bárcena, Juan | Blanco, Esther | Borrego, Belén | Dory, Daniel | Escribano, José M. | Le Gall-Reculé, Ghislaine | Ortego, Javier | Dixon, Linda K.
Developing vaccines for livestock provides researchers with the opportunity to perform efficacy testing in the natural hosts. This enables the evaluation of different strategies, including definition of effective antigens or antigen combinations, and improvement in delivery systems for target antigens so that protective immune responses can be modulated or potentiated. An impressive amount of knowledge has been generated in recent years on vaccine strategies and consequently a wide variety of antigen delivery systems is now available for vaccine research. This paper reviews several antigen production and delivery strategies other than those based on the use of live viral vectors. Genetic and protein subunit vaccines as well as alternative production systems are considered in this review.
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