Chemoenzymatic one-pot synthesis in an aqueous medium: combination of metal-catalysed allylic alcohol isomerisation–asymmetric bioamination
2015
Ríos-Lombardía, Nicolás | Vidal, Cristian | Cocina, María | Moris, Francisco | García-Álvarez, Joaquín | González-Sabín, Javier
The ruthenium-catalysed isomerisation of allylic alcohols was coupled, for the first time, with asymmetric bioamination in a one-pot process in an aqueous medium. In the cases involving prochiral ketones, the ω-TA exhibited excellent enantioselectivity, identical to that observed in the single step. As a result, amines were obtained from allylic alcohols with high overall yields and excellent enantiomeric excesses.
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