Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation
2013
Bischoff, Rainer | Bronsema, Kees J. | van de Merbel, Nico C. | Bronsema, Kees J. | van de Merbel, Nico C.
Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies.
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