Influence of graded levels of conjugated linoleic acid (CLA) on experimental atherosclerosis in rabbits
2002
Kritchevsky, David | Tepper, Shrley A. | Wright, Scott | Czarnecki, Susanne K.
Dietary CLA inhibits experimental atherosclerosis when fed at a level of 0.1%. In this study rabbits were fed 0.2% cholesterol as part of a semi-purified diet which contained 0, 0.05, 0.075, 0.10 or 0.5% CLA. At levels as low as 0.05% of the diet CLA reduced severity of atherosclerosis in the aortic arch by 20% and in the thoracic aorta by 8%. As dietary concentrations of CLA rose severity of atherosclerosis fell. When the diet contained 0.10% CLA severity of atherosclerosis in the aortic arch and thoracic aorta fell by 40 (p < 0.05) and 33%, respectively. CLA fed at 0.5% of the diet lowered severity of atherosclerosis in the aortic arch and thoracic aorta by 60% (p < 0.05) and 56% (p < 0.05), respectively. The effects observed at lower levels of CLA suggest effective levels of dietary CLA may be achieved in a normal human diet.
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