In vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles

Miller, C.D.; Richard, J.L.; Hembrough, F.B.; Osweiler, G.D.; Cox, D.F.

In vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles

1990

Miller, C.D. | Richard, J.L. | Hembrough, F.B. | Osweiler, G.D. | Cox, D.F.

An in vitro bioassay system was used to study the effects of cyclopiazonic acid (CPA) mycotoxin on cardiac muscle. Acute exposure to 6 microgram of CPA/ml of modified Krebs-Henseleit solution significantly (P < 0.05) decreased 5 in vitro turkey cardiac muscle performance criteria: maximal weight a muscle could lift; maximal contraction velocity; relaxation velocity; time to peak contraction; and total time for muscle contraction and relaxation. The effect on these 5 criteria appeared to result from intracellular changes partially associated with calcium availability and were irreversible, suggesting that physiologic changes had developed after acute exposure to CPA.

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