Anti‐Inflammatory Effects of Stearidonic Acid Mediated by Suppression of NF‐κB and MAP‐Kinase Pathways in Macrophages
2017
Sung, Jeehye | Jeon, Heemang | Kim, In‐Hwan | Jeong, Heon Sang | Lee, Junsoo
Stearidonic acid (SDA, 18:4n‐3) is an omega‐3 polyunsaturated fatty acid present in oils derived from plants of the Boraginaceae family. In this study, we determined the anti‐inflammatory effects of SDA isolated from echium oil on lipopolysaccharide (LPS)‐induced inflammatory responses in RAW 264.7 macrophages. SDA significantly downregulated the levels of the inducible nitric oxide synthase (iNOS) protein, thereby suppressing the production of nitric oxide (NO) in LPS‐stimulated RAW 264.7 cells. In addition, SDA inhibited the nuclear translocation and promoter activity of nuclear factor κB (NFκB) and the phosphorylation of mitogen‐activated protein kinases (MAPK) such as extracellular signal regulated kinase 1/2, c‐jun N terminal kinase, and p38 in LPS‐stimulated RAW 264.7 cells. Our results showed that SDA exerted anti‐inflammatory effects by suppressing iNOS‐mediated NO production via inactivation of NFκB and MAPK signaling pathways.
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