BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21Cᴵᴾ¹ pathway
2012
Zhang, Ju | Lou, Xiaomin | Yang, Shangbin | He, Shun | Yang, Lei | Liu, Mei | Zhu, Hongxia | Shan, Qiang | Su, Siyuan | Zhan, Qimin | Xu, Ningzhi | Liu, Siqi
Suppression of c-Myc is likely to induce cellular senescence in many tumors with unclear mechanisms. A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells. This observation led to the investigation into the role of BAG2 in c-Myc-induced senescence. The association of the c-Myc/SP1 complex with the BAG2 promoter verified the role of c-Myc/SP1 in regulating BAG2 transcription. Furthermore, high levels of BAG2 were found to induce p21Cᴵᴾ¹-dependent senescence and subsequent carcinogenetic arrest, suggesting its possible role as an indirect activator of the p21Cᴵᴾ¹ pathway.
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